| Date | Opponent | Result | W-L | Win | Loss | Save |
|---|---|---|---|---|---|---|
| April 5 | @ Padres | W, 5-3 | 1-0 | J. Lindblom | E. Volquez | J. Guerra |
| April 6 | @ Padres | W, 6-0 | 2-0 | C. Billingsley | C. Luebke | |
| April 7 | @ Padres | W, 6-5 (11) | 3-0 | T. Coffey | A. Bass | J. Guerra |
| April 8 | @ Padres | L, 8-4 | 3-1 | C. Richard | A. Harang | |
| April 10 | vs. Pirates | W, 2-1 | 4-1 | K. Jansen | J. Grilli | J. Guerra |
| April 11 | vs. Pirates | W, 4-1 | 5-1 | C. Billingsley | E. Bedard | J. Guerra |
| April 12 | vs. Pirates | W, 3-2 | 6-1 | C. Capuano | J. Kartsens | J. Guerra |
| April 13 | vs. Padres | W, 9-8 | 7-1 | K. Jansen | A. Cashner | |
| April 14 | vs. Padres | W, 6-1 | 8-1 | T. Lilly | J. Wieland | |
| April 15 | vs. Padres | W, 5-4 | 9-1 | J. Guerra | B. Brach | |
| April 17 | @ Brewers | L, 5-4 | 9-2 | J. Veras | J. Guerra | |
| April 18 | @ Brewers | L, 3-2 (10) | 9-3 | K. Loe | M. Guerrier | |
| April 19 | @ Brewers | W, 4-3 | 10-3 | A. Harang | R. Wolf | J. Guerra |
| April 20 | @ Astros | W, 3-1 | 11-3 | T. Lilly | J. Happ | J. Guerra |
| April 21 | @ Astros | W, 5-1 | 12-3 | C. Kershaw | K. Weiland | |
| April 22 | @ Astros | L, 12-0 | 12-4 | W. Rodriguez | C. Billingsley | |
| April 23 | vs. Braves | W, 7-2 | 13-4 | C. Capuano | J. Jurrjens | |
| April 24 | vs. Braves | L, 4-3 | 13-5 | E. O'Flaherty | J. Guerra | C. Kimbrel |
| April 25 | vs. Braves | L, 4-2 | 13-6 | J. Venters | J. Guerra | C. Kimbrel |
| April 27 | vs. Nationals | W, 3-2 | 14-6 | C. Kershaw | R. Detwiler | K. Jansen |
| April 28 | vs. Nationals | W, 4-3 (10) | 15-6 | J. Wright | T. Gorzelanny | |
| April 29 | vs. Nationals | W, 2-0 | 16-6 | C. Capuano | G. Gonzalez | K. Jansen |
| April 30 | @ Rockies | L, 6-2 | 16-7 | J. Nicasio | A. Harang | |
| May 1 | @ Rockies | W, 7-6 | 17-7 | T. Lilly | J. Chacin | J. Guerra |
| May 2 | @ Rockies | L, 8-5 | 17-8 | R. Betancourt | J. Wright | |
| May 4 | @ Cubs | L, 5-4 | 17-9 | P. Maholm | C. Billingsley | R. Dolis |
| May 5 | @ Cubs | W, 5-1 | 18-9 | C. Capuano | C. Volstad | |
| May 6 | @ Cubs | L, 4-3 (11) | 18-10 | R. Dolis | J. Wright | |
| May 7 | vs. Giants | W, 9-1 | 19-10 | T. Lilly | B. Zito | |
| May 8 | vs. Giants | L, 2-1 | 19-11 | R. Vogelsong | C. Kershaw | S. Casilla |
| May 9 | vs. Giants | W, 6-2 | 20-11 | J. Wright | T. Lincecum | |
| May 11 | vs. Rockies | W, 7-3 | 21-11 | C. Capuano | J. Moyer | |
| May 12 | vs. Rockies | W, 2-1 | 22-11 | A. Harang | J. Outman | K. Jansen |
| May 13 | vs. Rockies | W, 11-5 | 23-11 | T. Lilly | A. White | |
| May 14 | vs. D-Backs | W, 3-1 | 24-11 | C. Kershaw | I. Kennedy | K. Jansen |
| May 15 | vs. D-Backs | L, 5-1 | 24-12 | W. Miley | C. Billingsley | |
| May 16 | @ Padres | L, 4-2 | 24-13 | C. Richard | C. Capuano | D. Thayer |
| May 17 | @ Padres | W, 8-1 | 25-13 | A. Harang | E. Volquez | |
| May 18 | vs. Cardinals | W, 6-5 | 26-13 | K. Jansen | F. Salas | |
| May 19 | vs. Cardinals | W, 6-0 | 27-13 | C. Kershaw | J. Westbrook | |
| May 20 | vs. Cardinals | W, 6-5 | 28-13 | J. Guerra | M. Rzepczynski | K. Jansen |
| May 21 | @ D-Backs | W, 6-1 | 29-13 | C. Capuano | P. Corbin | |
| May 22 | @ D-Backs | W, 8-7 | 30-13 | J. Lindblom | J. Putz | K. Jansen |
| May 23 | @ D-Backs | L, 11-4 | 30-14 | J. Saunders | T. Lilly | |
| May 25 | vs. Astros | L, 3-1 | 30-15 | L. Harrell | C. Kershaw | B. Myers |
| May 26 | vs. Astros | W, 6-3 | 31-15 | K. Jansen | W. Wright | |
| May 27 | vs. Astros | W, 5-1 | 32-15 | C. Capuano | J. Happ | |
| May 28 | vs. Brewers | L, 3-2 | 32-16 | S. Marcum | A. Harang | J. Axford |
| May 29 | vs. Brewers | L, 2-1 | 32-17 | M. Fiers | N. Eovaldi | J. Axford |
| May 30 | vs. Brewers | L, 6-3 | 32-18 | Y. Gallardo | C. Kershaw | J. Axford |
| May 31 | vs. Brewers | L, 6-2 | 32-19 | Z. Greinke | C. Billingsley | |
| June 1 | @ Rockies | L, 13-3 | 32-20 | A. Ottavino | C. Capuano | |
| June 2 | @ Rockies | W, 6-2 | 33-20 | A. Harang | J. Nicasio | |
| June 3 | @ Rockies | L, 3-2 | 33-21 | A. White | N. Eovaldi | R. Betancourt |
| June 4 | @ Phillies | W, 4-3 | 34-21 | R. Belisario | J. Papelbon | K. Jansen |
| June 5 | @ Phillies | W, 2-1 | 35-21 | C. Billingsley | C. Lee | K. Jansen |
| June 6 | @ Phillies | W, 6-5 | 36-21 | C. Capuano | K. Kendrick | K. Jansen |
| June 7 | @ Phillies | W, 8-3 | 37-21 | A. Harang | C. Hamels | |
| June 8 | @ Mariners | L, 1-0 | 37-22 | S. Pryor | S. Elbert | T. Wilhelmsen |
| June 9 | @ Mariners | W, 8-3 | 38-22 | C. Kershaw | J. Vargas | |
| June 10 | @ Mariners | W, 8-2 | 39-22 | C. Billingsley | B. Beavan | |
| June 11 | vs. Angels | L, 3-2 | 39-23 | J. Isringhausen | K. Jansen | E. Frieri |
| June 12 | vs. Angels | W, 5-2 | 40-23 | J. Wright | J. Williams | K. Jansen |
| June 13 | vs. Angels | L, 2-1 | 40-24 | L. Hawkins | K. Jansen | E. Frieri |
| June 15 | vs. White Sox | W, 7-6 | 41-24 | R. Belisario | M. Thorton | K. Jansen |
| June 16 | vs. White Sox | L, 5-4 | 41-25 | P. Humber | C. Billingsley | A. Reed |
| June 17 | vs. White Sox | W, 2-1 (10) | 42-25 | R. Belisario | M. Thorton | |
| June 19 | @ Athletics | L, 3-0 | 42-26 | B. McCarthy | A. Harang | R. Cook |
| June 20 | @ Athletics | L, 4-1 | 42-27 | T. Milone | N. Eovaldi | |
| June 21 | @ Athletics | L, 4-1 | 42-28 | R. Cook | J. Lindblom | |
| June 22 | @ Angels | L, 8-5 | 42-29 | D. Haren | C. Billingsley | E. Frieri |
| June 23 | @ Angels | W, 3-1 | 43-29 | C. Capuano | E. Santana | K. Jansen |
| June 24 | @ Angels | L, 5-3 | 43-30 | S. Downs | J. Lindblom | E. Frieri |
| June 25 | @ Giants | L, 8-0 | 43-31 | B. Zito | N. Eovaldi | |
| June 26 | @ Giants | L, 2-0 | 43-32 | R. Vogelsong | C. Kershaw | S. Casilla |
| June 27 | @ Giants | L, 3-0 | 43-33 | T. Lincecum | C. Billingsley | S. Romo |
| June 28 | vs. Mets | L, 3-2 | 43-34 | C. Young | C. Capuano | B. Parnell |
| June 29 | vs. Mets | L, 9-0 | 43-35 | R. Dickey | A. Harang | |
| June 30 | vs. Mets | L, 5-0 | 43-36 | J. Santana | N. Eovaldi | |
| July 1 | vs. Mets | W, 8-3 | 44-36 | C. Kershaw | D. Gee | |
| July 2 | vs. Reds | L, 8-2 | 44-37 | H. Bailey | C. Billingsley | |
| July 3 | vs. Reds | W, 3-1 | 45-37 | S. Elbert | J. Cueto | K. Jansen |
| July 4 | vs. Reds | W, 4-1 | 46-37 | A. Harang | M. Leake | K. Jansen |
| July 5 | @ D-Backs | W, 4-1 | 47-37 | N. Eovaldi | W. Miley | K. Jansen |
| July 6 | @ D-Backs | L, 5-3 | 47-38 | J. Collmenter | C. Kershaw | J. Putz |
| July 7 | @ D-Backs | L, 5-3 | 47-39 | T. Cahill | C. Billingsley | J. Putz |
| July 8 | @ D-Backs | L, 7-1 | 47-40 | T. Bauer | C. Capuano | P. Corbin |
| July 13 | vs. Padres | W, 2-1 | 48-40 | C. Kershaw | C. Richard | K. Jansen |
| July 14 | vs. Padres | L, 7-6 | 48-41 | A. Hinshaw | K. Jansen | H. Street |
| July 15 | vs. Padres | L, 7-2 | 48-42 | J. Marquis | C. Capuano | |
| July 16 | vs. Phillies | L, 3-2 | 48-43 | J. Blanton | N. Eovaldi | J. Papelbon |
| July 17 | vs. Phillies | L, 3-2 | 48-44 | K. Kendrick | R. Belisario | J. Papelbon |
| July 18 | vs. Phillies | W, 5-3 (12) | 49-44 | J. Wright | J. Diekman | |
| July 20 | @ Mets | W, 7-6 | 50-44 | A. Harang | J. Santana | K. Jansen |
| July 21 | @ Mets | W, 8-5 | 51-44 | C. Capuano | M. Batista | K. Jansen |
| July 22 | @ Mets | W, 8-3 (12) | 52-44 | J. Wall | R. Ramirez | |
| July 23 | @ Cardinals | W, 5-3 | 53-44 | C. Billingsley | J. Kelly | K. Jansen |
| July 24 | @ Cardinals | L, 8-2 | 53-45 | A. Wainwright | C. Kershaw | |
| July 25 | @ Cardinals | L, 3-2 (12) | 53-46 | F. Salas | J. Wright | |
| July 26 | @ Cardinals | L, 7-4 | 53-47 | J. Westbrook | C. Capuano | J. Motte |
| July 27 | @ Giants | W, 5-3 (10) | 54-47 | S. Tolleson | S. Romo | K. Jansen |
| July 28 | @ Giants | W, 10-0 | 55-47 | C. Billingsley | B. Zito | |
| July 29 | @ Giants | W, 4-0 | 56-47 | C. Kershaw | R. Vogelsong | |
| July 30 | vs. D-Backs | L, 7-2 | 56-48 | T. Cahill | A. Harang | |
| July 31 | vs. D-Backs | L, 8-2 | 56-49 | W. Miley | C. Capuano | |
| Aug 1 | vs. D-Backs | L, 4-0 | 56-50 | P. Corbin | S. Fife | |
| Aug 3 | vs. Cubs | W, 6-1 | 57-50 | C. Billingsley | J. Samradjiza | |
| Aug 4 | vs. Cubs | W, 3-1 | 58-50 | C. Kershaw | C. Volstad | K. Jansen |
| Aug 5 | vs. Cubs | W, 7-6 | 59-50 | K. Jansen | S. Camp | |
| Aug 6 | vs. Rockies | L, 2-0 | 59-51 | A. Ottavino | C. Capuano | R. Betancourt |
| Aug 7 | vs. Rockies | L, 3-1 | 59-52 | J. Roenicke | A. Harang | R. Betancourt |
| Aug 8 | vs. Rockies | W, 6-4 | 60-52 | C. Billingsley | C. Torres | K. Jansen |
| Aug 10 | @ Marlins | W, 5-2 | 61-52 | C. Kershaw | M. Buehrle | K. Jansen |
| Aug 11 | @ Marlins | L, 7-3 | 61-53 | R. Nolasco | J. Blanton | |
| Aug 12 | @ Marlins | W, 5-0 | 62-53 | C. Capuano | W. LeBlanc | |
| Aug 13 | @ Pirates | W, 5-4 | 63-53 | A. Harang | J. Karstens | K. Jansen |
| Aug 14 | @ Pirates | W, 11-0 | 64-53 | C. Billingsley | K. Correia | |
| Aug 15 | @ Pirates | W, 9-3 | 65-53 | C. Kershaw | W. Rodriguez | |
| Aug 16 | @ Pirates | L, 10-6 | 65-54 | A. Burnett | J. Blanton | |
| Aug 17 | @ Braves | L, 4-3 (11) | 65-55 | J. Venters | B. League | |
| Aug 18 | @ Braves | W, 6-2 | 66-55 | A. Harang | B. Sheets | K. Jansen |
| Aug 19 | @ Braves | W, 5-0 | 67-55 | C. Billingsley | M. Minor | |
| Aug 20 | vs. Giants | L, 2-1 | 67-56 | M. Bumgarner | C. Kershaw | J. Lopez |
| Aug 21 | vs. Giants | L, 4-1 | 67-57 | T. Lincecum | J. Blanton | J. Lopez |
| Aug 22 | vs. Giants | L, 8-4 | 67-58 | M. Cain | C. Capuano | |
| Aug 24 | vs. Marlins | W, 11-4 | 68-58 | J. Wright | N. Eovaldi | |
| Aug 25 | vs. Marlins | W, 8-2 | 69-58 | C. Kershaw | J. Johnson | |
| Aug 26 | vs. Marlins | L, 6-2 | 69-59 | M. Buehrle | A. Harang | S. Cishek |
| Aug 27 | @ Rockies | L, 10-0 | 69-60 | J. Francis | J. Beckett | M. Belisle |
| Aug 28 | @ Rockies | L, 8-4 | 69-61 | T. Chatwood | C. Capuano | |
| Aug 29 | @ Rockies | W, 10-8 | 70-61 | J. Blanton | D. Pomeranz | R. Belisario |
| Au 30 | vs. D-Backs | L, 2-0 | 70-62 | I. Kennedy | C. Kershaw | J. Putz |
| Aug 31 | vs. D-Backs | L, 4-3 (11) | 70-63 | B. Bergesen | M. Gurrier | J. Putz |
| Sept 1 | vs. D-Backs | W, 2-1 | 71-63 | J. Beckett | M. Albers | B. League |
| Sept 2 | vs. D-Backs | W, 5-4 | 72-63 | R. Belisario | J. Putz | |
| Sept 3 | vs. Padres | W, 4-3 (11) | 73-63 | B. League | C. Burns | |
| Sept 4 | vs. Padres | L, 6-3 (11) | 73-64 | T. Layne | J. Ely | L. Gregorson |
| Sept 5 | vs. Padres | L, 4-3 | 73-65 | N. Vincent | S. Tolleson | T. Layne |
| Sept 7 | @ Giants | L, 5-2 | 73-66 | S. Casilla | J. Beckett | S. Romo |
| Sept 8 | @ Giants | W, 3-2 | 74-66 | R. Belisario | J. Affeldt | B. League |
| Sept 9 | @ Giants | L, 4-0 | 74-67 | B. Zito | J. Blanton | |
| Sept 11 | @ D-Backs | L, 1-0 | 74-68 | I. Kennedy | C. Kershaw | D. Hernandez |
| Sept 12 | @ D-Backs | L, 3-2 | 74-69 | T. Cahill | A. Harang | D. Hernandez |
| Sept 13 | vs. Cardinals | L, 2-1 | 74-70 | L. Lynn | P. Rodriguez | J. Motte |
| Sept 14 | vs. Cardinals | W, 8-5 | 75-70 | S. Tolleson | T. Rosenthal | |
| Sept 15 | vs. Cardinals | W, 4-3 | 76-70 | R. Belisario | J. Motte | |
| Sept 16 | vs. Cardinals | L, 5-2 (12) | 76-71 | S. Miller | J. Ely | J. Motte |
| Sept 18 | @ Nationals | PPD | 76-71 | N/A | N/A | N/A |
| Sept 19 | @ Nationals | L, 3-1 | 76-72 | J. Zimmerman | A. Harang | T. Clippard |
| Sept 19 | @ Nationals | W, 7-6 | 77-72 | R. Belisario | T. Clippard | B. League |
| Sept 20 | @ Nationals | L, 4-1 | 77-73 | R. Detwiler | C. Capuano | D. Storen |
| Sept 21 | @ Reds | W, 3-1 (10) | 78-73 | R. Belisario | S. LeCure | B. League |
| Sept 22 | @ Reds | L, 6-0 | 78-74 | M. Latos | S. Fife | |
| Sept 23 | @ Reds | W, 5-3 | 79-74 | S. Tolleson | H. Bailey | B. League |
| Sept 25 | @ Padres | L, 2-1 | 79-75 | E. Volquez | J. Beckett | H. Street |
| Sept 26 | @ Padres | W, 8-2 | 80-75 | A. Harang | C. Richard | |
| Sept 27 | @ Padres | W, 8-4 | 81-75 | C. Capuano | C. Kelly | |
| Sept 28 | vs. Rockies | W, 8-0 | 82-75 | C. Kershaw | J. Francis | |
| Sept 29 | vs. Rockies | W, 3-0 | 83-75 | J. Blanton | T. Chatwood | B. League |
| Sept 30 | vs. Rockies | W, 7-1 | 84-75 | J. Beckett | J. De La Rosa | |
| Oct 1 | vs. Giants | W, 3-2 | 85-75 | B. League | S. Casilla | |
| Oct 2 | vs. Giants | L, 4-3 | 85-76 | B. Zito | C. Capuano | S. Romo |
| Oct 3 | vs. Giants | W, 5-1 | 86-76 | C. Kershaw | C. Hensley |
